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dc.contributor.authorGodoy, Maria Dantas Costa Limaen
dc.contributor.authorFornazieri, Marco Aurélioen
dc.contributor.authorDoty, Richard L.en
dc.contributor.authorPinna, Fábio de Rezendeen
dc.contributor.authorFarfel, José Marceloen
dc.contributor.authorSantos, Glaucia Bento dosen
dc.contributor.authorMolina, Marianaen
dc.contributor.authorFerretti-Rebustini, Renata E. L.en
dc.contributor.authorLeite, Renata E. P.en
dc.contributor.authorSuemoto, Claudia K.en
dc.contributor.authorGrinberg, Lea T.en
dc.contributor.authorPasqualucci, Carlos A. G.en
dc.contributor.authorVoegels, Richard Louisen
dc.contributor.authorNitrini, Ricardoen
dc.contributor.authorJacob Filho, Wilsonen
dc.date.accessioned2020-09-14T13:50:42Z
dc.date.available2020-09-14T13:50:42Z
dc.date.issued2019-03
dc.identifier.citationGodoy MDCL, Fornazieri MA, Doty RL, Pinna FR, Farfel JM, Santos GBD, Molina M, Ferretti-Rebustini REL, Leite REP, Suemoto CK, Grinberg LT, Pasqualucci CAG, Voegels RL, Nitrini R, Jacob Filho W. Is Olfactory Epithelium Biopsy Useful for Confirming Alzheimer's Disease? Ann Otol Rhinol Laryngol. 2019 Mar;128(3):184-192. Doi: 10.1177/0003489418814865.en
dc.identifier.other10.1177/0003489418814865
dc.identifier.urihttp://digital.bibliotecaorl.org.br/handle/forl/437
dc.description.abstractOBJECTIVES: The clinical symptoms of Alzheimer’s disease (AD) are preceded by a long asymptomatic period associated with “silent” deposition of aberrant paired helical filament (PHF)-tau and amyloid-beta proteins in brain tissue. Similar depositions have been reported within the olfactory epithelium (OE), a tissue that can be biopsied in vivo. The degree to which such biopsies are useful in identifying AD is controversial. This postmortem study had 3 main goals: first, to quantify the relative densities of AD-related proteins in 3 regions of the olfactory neuroepithelium, namely, the nasal septum, middle turbinate, and superior turbinate; second, to establish whether such densities are correlated among these epithelial regions as well as with semi-quantitative ratings of general brain cortex pathology; and third, to evaluate correlations between the protein densities and measures of antemortem cognitive function.en
dc.language.isoen_USen
dc.publisherAnn Otol Rhinol Laryngol. 2019 Mar;128(3):184-192. doi: 10.1177/0003489418814865.
dc.source.urihttps://doi.org/10.1177/0003489418814865
dc.subjectAlzheimer’s Diseaseen
dc.subjectAgingen
dc.subjectImmunohistochemistryen
dc.subjectOlfactory Mucosaen
dc.subjectOlfactionen
dc.subjectOlfaction Disordersen
dc.titleIs Olfactory Epithelium Biopsy Useful for Confirming Alzheimer's Disease?en
dc.title.alternativeAnn Otol Rhinol Laryngol. 2019 Mar;128(3):184-192. doi: 10.1177/0003489418814865.en
dc.typeArtigoen


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